Janssen CarePath can:

  • Review your health plan benefits to help answer questions you may have about insurance coverage for UPTRAVI®
  • Identify options that may help make UPTRAVI® more affordable, if needed
  • Connect you with a dedicated PAH Companion* for one-on-one educational conversations and support
  • Identify and coordinate with a specialty pharmacy to arrange shipment of your Janssen medication

*The PAH Companion Program is limited to education about your Janssen therapy, its administration, and/or PAH. It is intended to supplement your understanding of your therapy, and does not provide medical advice or replace a treatment plan from your doctor, nurse, or healthcare team.

Getting Started with UPTRAVI®

UPTRAVI® is delivered by a specialty pharmacy—it's not something that's kept in stock at your local retail pharmacy. The following is a typical process when starting out with UPTRAVI®, though your experience may vary.

  1. Prescription Prescription

    Your healthcare provider prescribes UPTRAVI®.

    • Your healthcare team will review important information about UPTRAVI® with you
    • They can help you enroll with Janssen CarePath
    • Your prescription will be sent to a specialty pharmacy
    • Your healthcare provider will work with you to select the specialty pharmacy support services that are right for you when starting UPTRAVI®, such as an in-home nurse visit
  2. Insurance Verification Insurance verification

    The insurance company may ask your healthcare provider for additional information before they pay for your medicine.

    • A Janssen CarePath Care Coordinator can help with this process by gathering additional information from your healthcare team
  3. Delivery of Medicine Delivery of medicine

    UPTRAVI® is shipped to you by a specialty pharmacy.

    • A Janssen CarePath Coordinator will help you connect with a specialty pharmacy that delivers UPTRAVI® in your area
    • Each month, the specialty pharmacy will call you to confirm details of the delivery and arrange your refill
    • You may receive additional services, such as nurse-supported education during your dose adjustment (titration) phase

    Remember, the call from your specialty pharmacy may come from a phone number that you don't know. If you miss the call, it's important that you call back.

  4. Refills Refills

    Before your medicine ships each month, your specialty pharmacy will call you to alert you.

Your Janssen CarePath Care Coordinator may need additional information from you at the start of treatment

When you speak with a Care Coordinator, they may ask for additional information, including:

  • Details of your healthcare plan, including the name and contact information for the insurance company and your policy number
  • The name and contact information of your prescribing doctor (including the fax number)
  • Further details from your healthcare team, if your initial claim is denied

If you change insurance plans or healthcare providers, speak with your healthcare team and a Care Coordinator in a timely manner to make sure you can continue your treatment.

Contact a Care Coordinator with questions at 866-228-3546, Monday–Friday, 8:00 AM to 8:00 PM ET.

Working With a Specialty Pharmacy

We understand that it is important for you to get your medicine in a timely manner. After you enroll with Janssen CarePath, you will get a call to walk you through the process and discuss medicine delivery. Here are the basic steps you will need to take to fill your UPTRAVI® prescription.

Steps of the specialty pharmacy process

  • Learn about specialty pharmacies.
    Certain medicines, such as UPTRAVI®, aren't kept at your local retail pharmacy. Instead, a specialty pharmacy will ship UPTRAVI® directly to your home.
  • Find the right specialty pharmacy for you.
    Either CVS Specialty or Accredo will call you to discuss financial responsibilities and shipment information.

    You or your healthcare provider may have chosen additional support services such as an in-home nurse visit. Your specialty pharmacy will help you schedule this.

  • Finding the dose that is right for you.
    It can take time for your body to adjust to UPTRAVI®. You may experience side effects as part of the process of finding the dose that is right for you. This is expected and more likely to occur when starting UPTRAVI® or when your healthcare provider changes your dose.

    You can download the Dose Adjustment Phase Guide that highlights important steps and information about titration with UPTRAVI®.

  • Once you find the right dose, continue on your treatment.
    Each month, the specialty pharmacy will call you to confirm details of the delivery and to arrange your refill.

NOTE: The specialty pharmacy may not ship your medicine if they don't speak with you first. Be sure to answer when they call and call them back if they leave a message.

If your health plan does not approve UPTRAVI® treatment

Sometimes you may not be able to obtain the medication that your doctor has ordered for you. For example, your health plan might not cover the medication because it is not on the plan’s drug list (formulary) or the cost is higher than you think you should have to pay. In these situations, you and your doctor have the right to ask the health plan to explain its decision and to consider making the medication available to you as an exception to its policies.


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What is UPTRAVI®?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI® can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI® is safe and effective in children.


  • Do not take UPTRAVI® if you take gemfibrozil because this medicine may affect how UPTRAVI® works and cause side effects
  • Do not take UPTRAVI® if you are allergic to selexipag or any of the ingredients in UPTRAVI®
  • Before you take UPTRAVI®, tell your healthcare provider about all your medical conditions, including if you:
    • Have liver problems
    • Have narrowing of the pulmonary veins (veins in your lungs). This is called pulmonary veno-occlusive disease (PVOD)
    • Are pregnant or plan to become pregnant. It is not known if UPTRAVI® will harm your unborn baby
    • Are breastfeeding or plan to breastfeed. It is not known if UPTRAVI® passes into your breast milk. You and your doctor should decide if you will take UPTRAVI® or breastfeed. You should not do both
    • Are taking any other prescription or over-the-counter medicines, vitamins, or herbal supplements

What are the possible side effects of UPTRAVI®?

The most common side effects are:

  • Headache
  • Diarrhea
  • Jaw pain
  • Nausea
  • Muscle pain
  • Vomiting
  • Pain, redness or swelling at the injection site with UPTRAVI® for injection
  • Pain in arms or legs
  • Temporary reddening of the skin (flushing)
  • Joint pain
  • Low red blood cell count
  • Less appetite than usual
  • Rash

Talk to your doctor if you have a side effect that bothers you or does not go away. These are not all the possible side effects of UPTRAVI®. For more information, ask your doctor or pharmacist.

You may report side effects to FDA at 1-800-FDA-1088 or

Keep UPTRAVI® and all other medicines away from children.

What other medicines might interact with UPTRAVI®?

UPTRAVI® and other medicines may affect each other, causing side effects. Tell your doctor about all the medicines you are taking. Do not start any new medicine until you check with your doctor.

How should I take UPTRAVI®?

UPTRAVI® Tablets

  • Take UPTRAVI® exactly as your doctor tells you to take it. Usually, your doctor will have you take UPTRAVI® twice a day. Taking UPTRAVI® with food may help you tolerate UPTRAVI® better
  • Swallow UPTRAVI® tablets whole. Do not split, crush, or chew tablets
  • Tell your doctor if you have any form of liver disease. Your doctor may need to change your dose of UPTRAVI®
  • UPTRAVI® is measured in micrograms (mcg). Tablets come in the following strengths: 200, 400, 600, 800, 1000, 1200, 1400, and 1600 mcg

UPTRAVI® given by intravenous (IV) injection

  • Your healthcare provider will give you UPTRAVI® into your vein through an intravenous (IV) line
  • Your healthcare provider will decide how much UPTRAVI® for injection you will receive each day based on your current dose of UPTRAVI® tablets

Please see full Prescribing Information and Patient Product Information.