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Janssen Compass™

Look to Janssen Compass™ to help you understand your insurance coverage and cost support options, as well as guide you in navigating educational resources you want and need to feel confident on your Janssen therapy.

Throughout the program you can:

Connect... each time to the same Janssen Compass™ Care Navigator who understands and offers education on your cancer and your Janssen medication

Learn... about resources to support you with cost, coverage, your personal wellness, and your emotional wellbeing throughout your treatment journey and beyond

Simplify... your experience through personalized education, every step of the way, to build confidence in what to expect and support in making decisions about your treatment with your doctor and loved ones

Your Janssen Compass™ Care Navigator is a phone call away!

To schedule an introductory call with a Janssen Compass™ Care Navigator:

  1. Text "CALL" to 844-628-1234.
  2. Visit .
  3. Call 844-628-1234, Monday through Friday from 8:30 AM - 8:30 PM ET.

We will ask for your name and ZIP code, and you will receive a call from a dedicated Janssen Compass™ Care Navigator within 1 business day.

The personal information you provide about yourself through text message will be used by Janssen Biotech, Inc., its affiliates, and the program's service providers (collectively Janssen) to contact you by phone to describe the Janssen Compass™ program and complete the enrollment process. The Privacy Policy further explains how Janssen processes the personal information you provide. By texting "CALL", you indicate that you have read, understand, and agree to these terms.

By texting "CALL" to 844-628-1234, you consent to receive automated text messages from the Janssen Compass™ program to schedule a call with a dedicated Care Navigator and to learn more about the program. Please note that text message and data rates may apply. You may opt out any time by texting "STOP" to 844-628-1234. Please do not share any unprompted personal or medical information, as we are not able to reply to messages other than "CALL". If you have specific questions, please call a Janssen Compass™ Care Navigator at 844-628-1234 Monday - Friday from 8:30 AM - 8:30 PM. Call your doctor for medical advice about side effects. You may report side effects to the Janssen Medical Information Center by calling 800-526-7736.

Janssen Compass™ is limited to education for patients about their Janssen therapy, its administration, and/or their disease. It is intended to supplement a patient's understanding of their therapy and is not intended to provide medical advice, replace a treatment plan from the patient's doctor or nurse, provide case management services, or serve as a reason to prescribe this medication.

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IMPORTANT SAFETY INFORMATION
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What is RYBREVANT® (amivantamab-vmjw)?

RYBREVANT® is a prescription medicine used to treat adults:

  • in combination with carboplatin and pemetrexed as a first-line treatment for non-small cell lung cancer (NSCLC) that:
    • has spread to other parts of the body (metastatic) or cannot be removed by surgery, and
    • has a certain abnormal epidermal growth factor receptor “EGFR” gene(s)
  • alone for the treatment of non-small cell lung cancer (NSCLC) that:
    • has spread to other parts of the body (metastatic) or cannot be removed by surgery, and
    • has a certain abnormal EGFR gene(s), and whose disease has worsened on or after platinum-based chemotherapy.

Your healthcare provider will perform a test to make sure that RYBREVANT® is right for you. It is not known if RYBREVANT® is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Before you receive RYBREVANT®, tell your healthcare provider about all of your medical conditions, including if you:

  • have a history of lung or breathing problems.
  • are pregnant or plan to become pregnant. RYBREVANT® can harm your unborn baby.

Females who are able to become pregnant:

  • Your healthcare provider should do a pregnancy test before you start treatment with RYBREVANT®.
  • You should use effective birth control (contraception) during treatment and for 3 months after your final dose of RYBREVANT®.
  • Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with RYBREVANT®.
  • are breastfeeding or plan to breastfeed. It is not known if RYBREVANT® passes into your breast milk. Do not breastfeed during treatment and for 3 months after your final dose of RYBREVANT®.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive RYBREVANT®?

  • RYBREVANT® will be given to you by your healthcare provider by intravenous infusion into your vein.
  • Your healthcare provider will decide the time between doses as well as how many treatments you will receive.
  • Your healthcare provider will give you medicines before each dose of RYBREVANT® to help reduce the risk of infusion-related reactions.
  • RYBREVANT® may be given in combination with the medicines carboplatin and pemetrexed. If you have any questions about these medicines, ask your healthcare provider.
  • If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment.

What should I avoid while receiving RYBREVANT®?

RYBREVANT® can cause skin reactions. You should limit your time in the sun during and for 2 months after your treatment with RYBREVANT®. Wear protective clothing and use sunscreen during treatment with RYBREVANT®.

What are the possible side effects of RYBREVANT®?

RYBREVANT® may cause serious side effects, including:

  • infusion-related reactions. Infusion-related reactions are common with RYBREVANT® and can be severe or serious. Tell your healthcare provider right away if you get any of the following symptoms during your infusion of RYBREVANT®:
  • shortness of breath
  • fever
  • chills
  • nausea
  • flushing
  • chest discomfort
  • lightheadedness
  • vomiting
  • lung problems. RYBREVANT® may cause lung problems that may lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you get any new or worsening lung symptoms, including shortness of breath, cough, or fever.
  • skin problems. RYBREVANT® may cause rash, itching, and dry skin. You may use alcohol-free moisturizing cream for dry skin. Tell your healthcare provider right away if you get any skin reactions. Your healthcare provider may treat you with a medicine(s) or send you to see a skin specialist (dermatologist) if you get skin reactions during treatment with RYBREVANT®. See “What should I avoid while receiving RYBREVANT®?”
  • eye problems. RYBREVANT® may cause eye problems. Tell your healthcare provider right away if you get symptoms of eye problems which may include:
  • eye pain
  • dry eyes
  • eye redness
  • blurred vision
  • changes in vision
  • itchy eyes
  • excessive tearing
  • sensitivity to light

Your healthcare provider may send you to see an eye specialist (ophthalmologist) if you get eye problems during treatment with RYBREVANT®. You should not use contact lenses until your eye symptoms are checked by a healthcare provider.

The most common side effects of RYBREVANT® in combination with carboplatin and pemetrexed include:

  • rash
  • infected skin around the nail
  • sores in the mouth
  • infusion-related reactions
  • feeling very tired
  • swelling of hands, ankles, feet, face, or all of your body
  • constipation
  • decreased appetite
  • nausea
  • COVID-19
  • diarrhea
  • vomiting
  • changes in certain blood tests

The most common side effects of RYBREVANT® when given alone:

  • rash
  • infusion-related reactions
  • infected skin around the nail
  • muscle and joint pain
  • shortness of breath
  • nausea
  • feeling very tired
  • swelling of hands, ankles, feet, face, or all of your body
  • sores in the mouth
  • cough
  • constipation
  • vomiting
  • changes in certain blood tests

Your healthcare provider may temporarily stop, decrease your dose, or completely stop your treatment with RYBREVANT® if you have serious side effects.

These are not all of the possible side effects of RYBREVANT®.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1‑800‑FDA‑1088.

General information about the safe and effective use of RYBREVANT®:

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your healthcare provider or pharmacist for information about RYBREVANT® that is written for health professionals.

Please read full Prescribing Information for RYBREVANT®.

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