ICD-10 Support

ICD-10 Support

The ICD-10 Diagnosis Codes for Providers

The table below lists ICD-10 diagnosis codes that you may need for patients treated with REMICADE®. These codes are not intended to be promotional or to suggest a use that is inconsistent with FDA-approved use. The list is not exhaustive and additional codes may apply. ICD-10 codes use 3 to 7 alpha and numeric characters. A code is invalid if it does not use the full number of characters required, including the 7th character, if applicable.

Click Below to See the Codes


ICD-10 Codes
Rheumatoid arthritis with rheumatoid factor without organ or systems involvement M05.7XX

More codes

... of unspecified site M05.70
... of right shoulder M05.711
... of left shoulder M05.712
... of unspecified shoulder M05.719
... of right elbow M05.721
... of left elbow M05.722
... of unspecified elbow M05.729
... of right wrist M05.731
... of left wrist M05.732
... of unspecified wrist M05.739
... of right hand M05.741
... of left hand M05.742
... of unspecified hand M05.749
... of right hip M05.751
... of left hip M05.752
... of unspecified hip M05.759
... of right knee M05.761
... of left knee M05.762
... of unspecified knee M05.769
... of right ankle and foot M05.771
... of left ankle and foot M05.772
... of unspecified ankle and foot M05.779
... of multiple sites M05.79
Other rheumatoid arthritis with rheumatoid factor M05.8XX

More codes

... of unspecified site M05.80
... of right shoulder M05.811
... of left shoulder M05.812
... of unspecified shoulder M05.819
... of right elbow M05.821
... of left elbow M05.822
... of unspecified elbow M05.829
... of right wrist M05.831
... of left wrist M05.832
... of unspecified wrist M05.839
... of right hand M05.841
... of left hand M05.842
... of unspecified hand M05.849
... of right hip M05.851
... of left hip M05.852
... of unspecified hip M05.859
... of right knee M05.861
... of left knee M05.862
... of unspecified knee M05.869
... of right ankle and foot M05.871
... of left ankle and foot M05.872
... of unspecified ankle and foot M05.879
... of multiple sites M05.89
Rheumatoid arthritis with rheumatoid factor, unspecified M05.9
Other Rheumatoid Arthritis M06
Rheumatoid arthritis without rheumatoid factor M06.0XX

More codes

..., unspecified site M06.00
..., right shoulder M06.011
..., left shoulder M06.012
..., unspecified shoulder M06.019
..., right elbow M06.021
..., left elbow M06.022
..., unspecified elbow M06.029
..., right wrist M06.031
..., left wrist M06.032
..., unspecified wrist M06.039
..., right hand M06.041
..., left hand M06.042
..., unspecified hand M06.049
..., right hip M06.051
..., left hip M06.052
..., unspecified hip M06.059
..., right knee M06.061
..., left knee M06.062
..., unspecified knee M06.069
..., right ankle and foot M06.071
..., left ankle and foot M06.072
..., unspecified ankle and foot M06.079
..., vertebrae M06.08
..., multiple sites M06.09
Other specified rheumatoid arthritis M06.8XX

More codes

..., unspecified site M06.80
..., right shoulder M06.811
..., left shoulder M06.812
..., unspecified shoulder M06.819
..., right elbow M06.821
..., left elbow M06.822
..., unspecified elbow M06.829
..., right wrist M06.831
..., left wrist M06.832
..., unspecified wrist M06.839
..., right hand M06.841
..., left hand M06.842
..., unspecified hand M06.849
..., right hip M06.851
..., left hip M06.852
..., unspecified hip M06.859
..., right knee M06.861
..., left knee M06.862
..., unspecified knee M06.869
..., right ankle and foot M06.871
..., left ankle and foot M06.872
..., unspecified ankle and foot M06.879
..., vertebrae M06.88
..., multiple sites M06.89
Rheumatoid arthritis, unspecified M06.9


ICD-10 Codes
Psoriasis vulgaris
Plaque psoriasis


ICD-10 Codes
Arthropathic psoriasis L40.5
Arthropathic psoriasis, unspecified L40.50
Distal interphalangeal psoriatic arthropathy L40.51
Psoriatic arthritis mutilans L40.52
Psoriatic spondylitis L40.53
Other psoriatic arthropathy L40.59


ICD-10 Codes
Ankylosing spondylitis M45
... of multiple sites in spine M45.0
... of occipito-atlanto-axial region M45.1
... of cervical region M45.2
... of cervicothoracic region M45.3
... of thoracic region M45.4
... of thoracolumbar region M45.5
... of lumbar region M45.6
... of lumbosacral region M45.7
... of sacral and sacrococcygeal region M45.8
... of unspecified sites in spine M45.9


ICD-10 Codes
Crohn's disease (regional enteritis) K50
Crohn's disease of small intestine without complications K50.00
Crohn's disease of small intestine with complications K50.01
Crohn's disease of large intestine without complications K50.10
Crohn's disease of large intestine with complications K50.11
Crohn's disease of both small and large intestine without complications K50.80
Crohn's disease of both small and large intestine with complications K50.81
Crohn's disease, unspecified, without complications K50.90
Crohn's disease, unspecified, with complications K50.91


ICD-10 Codes
Ulcerative Colitis K51
Ulcerative (chronic) pancolitis without complications K51.00
Ulcerative (chronic) pancolitis with complications K51.01
Ulcerative (chronic) proctitis without complications K51.20
Ulcerative (chronic) proctitis with complications K51.21
Ulcerative (chronic) rectosigmoiditis without complications K51.30
Ulcerative (chronic) rectosigmoiditis with complications K51.31
Left sided colitis without complications K51.50
Left sided colitis with complications K51.51
Other ulcerative colitis without complications K51.80
Other ulcerative colitis with complications K51.81
Ulcerative colitis, unspecified, without complications K51.90
Ulcerative colitis, unspecified, with complications K51.91


Collected in 12/21 and may change.

This information is not a promise of coverage or payment. It is not intended to give reimbursement advice or increase reimbursement by any payer. Legal requirements and plan information can be updated frequently. Contact the plan for more information about current coverage, reimbursement policies, restrictions, or requirements that may apply.

For more information on ICD-10, visit the CMS website.

ICD-10-CM 2021: The Official Codebook. American Medical Association, 2020.


Crohn's Disease

REMICADE® is indicated for:

  • reducing signs and symptoms and inducing and maintaining clinical remission in adult patients with moderately to severely active Crohn's disease (CD) who have had an inadequate response to conventional therapy.
  • reducing the number of draining enterocutaneous and rectovaginal fistulas and maintaining fistula closure in adult patients with fistulizing CD.

Pediatric Crohn's Disease

REMICADE® is indicated for reducing signs and symptoms and inducing and maintaining clinical remission in pediatric patients 6 years of age and older with moderately to severely active CD who have had an inadequate response to conventional therapy.

Ulcerative Colitis

REMICADE® is indicated for reducing signs and symptoms, inducing and maintaining clinical remission and mucosal healing, and eliminating corticosteroid use in adult patients with moderately to severely active ulcerative colitis (UC) who have had an inadequate response to conventional therapy.

Pediatric Ulcerative Colitis

REMICADE® is indicated for reducing signs and symptoms and inducing and maintaining clinical remission in pediatric patients 6 years of age and older with moderately to severely active UC who have had an inadequate response to conventional therapy.

Rheumatoid Arthritis

REMICADE®, in combination with methotrexate, is indicated for reducing signs and symptoms, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active rheumatoid arthritis (RA).

Ankylosing Spondylitis

REMICADE® is indicated for reducing signs and symptoms in adult patients with active ankylosing spondylitis (AS).

Psoriatic Arthritis

REMICADE® is indicated for reducing signs and symptoms of active arthritis, inhibiting the progression of structural damage, and improving physical function in adult patients with psoriatic arthritis (PsA).

Plaque Psoriasis

REMICADE® is indicated for the treatment of adult patients with chronic severe (i.e., extensive and/or disabling) plaque psoriasis (Ps) who are candidates for systemic therapy and when other systemic therapies are medically less appropriate. REMICADE® should only be administered to patients who will be closely monitored and have regular follow-up visits with a physician.

Important Safety Information For REMICADE®


Patients treated with REMICADE® (infliximab) are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. Discontinue REMICADE® if a patient develops a serious infection or sepsis.

Reported infections include:

  • Active tuberculosis (TB), including reactivation of latent TB. Patients frequently presented with disseminated or extrapulmonary disease. Patients should be tested for latent TB before and during treatment with REMICADE®.1,2 Treatment for latent infection should be initiated prior to treatment with REMICADE®.
  • Invasive fungal infections, including histoplasmosis, coccidioidomycosis, candidiasis, aspergillosis, blastomycosis, pneumocystosis, and cryptococcosis. Patients may present with disseminated, rather than localized, disease. Empiric anti-fungal therapy should be considered in patients at risk for invasive fungal infections who develop severe systemic illness.
  • Bacterial, viral, and other infections due to opportunistic pathogens, including Legionella, Listeria, and Salmonella.

The risks and benefits of treatment with REMICADE® should be carefully considered prior to initiating therapy in patients with chronic or recurrent infection. Closely monitor patients for the development of signs and symptoms of infection during and after treatment with REMICADE®, including the possible development of TB in patients who tested negative for latent TB infection prior to initiating therapy, who are on treatment for latent TB, or who were previously treated for TB infection.

Risk of infection may be higher in patients greater than 65 years of age, pediatric patients, patients with co-morbid conditions and/or patients taking concomitant immunosuppressant therapy. In clinical trials, other serious infections observed in patients treated with REMICADE® included pneumonia, cellulitis, abscess, and skin ulceration.


Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, including REMICADE®. Approximately half of these cases were lymphomas, including Hodgkin's and non-Hodgkin's lymphoma. The other cases represented a variety of malignancies, including rare malignancies that are usually associated with immunosuppression and malignancies that are not usually observed in children and adolescents. The malignancies occurred after a median of 30 months after the first dose of therapy. Most of the patients were receiving concomitant immunosuppressants.

Postmarketing cases of hepatosplenic T-cell lymphoma, a rare type of T-cell lymphoma, have been reported in patients treated with TNF blockers, including REMICADE®. These cases have had a very aggressive disease course and have been fatal. The majority of reported REMICADE® cases have occurred in patients with Crohn’s disease or ulcerative colitis and most were in adolescent and young adult males. Almost all of these patients had received treatment with azathioprine or 6-mercaptopurine concomitantly with REMICADE® at or prior to diagnosis. Carefully assess the risks and benefits of treatment with REMICADE®, especially in these patient types.

In clinical trials of all TNF blockers, more cases of lymphoma were observed compared with controls and the expected rate in the general population. However, patients with Crohn’s disease, rheumatoid arthritis, or plaque psoriasis may be at higher risk for developing lymphoma. In clinical trials of some TNF inhibitors, including REMICADE®, more cases of other malignancies were observed compared with controls. The rate of these malignancies among patients treated with REMICADE® was similar to that expected in the general population whereas the rate in control patients was lower than expected. Cases of acute and chronic leukemia have been reported with postmarketing TNF-blocker use. As the potential role of TNF blockers in the development of malignancies is not known, caution should be exercised when considering treatment of patients with a current or a past history of malignancy or other risk factors such as chronic obstructive pulmonary disease (COPD).

Melanoma and Merkel cell carcinoma have been reported in patients treated with TNF-blocker therapy, including REMICADE®. Periodic skin examination is recommended for all patients, particularly those with risk factors for skin cancer.

A population-based retrospective cohort study found a 2- to 3-fold increase in the incidence of invasive cervical cancer in women with rheumatoid arthritis treated with REMICADE® compared to biologics-naïve patients or the general population, particularly those over 60 years of age. A causal relationship between REMICADE® and cervical cancer cannot be excluded. Periodic screening should continue in women treated with REMICADE®.


The use of REMICADE® at doses >5 mg/kg is contraindicated in patients with moderate or severe heart failure. REMICADE® is contraindicated in patients with a previous severe hypersensitivity reaction to infliximab or any of the inactive ingredients of REMICADE® or any murine proteins (severe hypersensitivity reactions have included anaphylaxis, hypotension, and serum sickness).


TNF blockers, including REMICADE®, have been associated with reactivation of hepatitis B virus (HBV) in patients who are chronic carriers. Some cases were fatal. Patients should be tested for HBV infection before initiating REMICADE®. For patients who test positive, consult a physician with expertise in the treatment of hepatitis B. Exercise caution when prescribing REMICADE® for patients identified as carriers of HBV and monitor closely for active HBV infection during and following termination of therapy with REMICADE®. Discontinue REMICADE® in patients who develop HBV reactivation and initiate antiviral therapy with appropriate supportive treatment. Exercise caution when considering resumption of REMICADE® and monitor patients closely.


Severe hepatic reactions, including acute liver failure, jaundice, hepatitis, and cholestasis have been reported in patients receiving REMICADE® postmarketing. Some cases were fatal or required liver transplant. Aminotransferase elevations were not noted prior to discovery of liver injury in many cases. Patients with symptoms or signs of liver dysfunction should be evaluated for evidence of liver injury. If jaundice and/or marked liver enzyme elevations (eg, ≥5 times the upper limit of normal) develop, REMICADE® should be discontinued, and a thorough investigation of the abnormality should be undertaken.


In a randomized, placebo-controlled study in patients with moderate or severe heart failure (NYHA Functional Class III/IV), higher mortality rates and a higher risk of hospitalization were observed at Week 28 at a dose of 10 mg/kg and higher rates of cardiovascular events were observed at both 5 mg/kg and 10 mg/kg. There have been postmarketing reports of new onset and worsening heart failure, with and without identifiable precipitating factors. Patients with moderate or severe heart failure taking REMICADE® (≤5 mg/kg) or patients with mild heart failure should be closely monitored and treatment should be discontinued if new or worsening symptoms appear.


Cases of leukopenia, neutropenia, thrombocytopenia, and pancytopenia (some fatal) have been reported. The causal relationship to REMICADE® therapy remains unclear. Exercise caution in patients who have ongoing or a history of significant hematologic abnormalities. Advise patients to seek immediate medical attention if they develop signs and symptoms of blood dyscrasias or infection. Consider discontinuation of REMICADE® in patients who develop significant hematologic abnormalities.


REMICADE® has been associated with hypersensitivity reactions that differ in their time of onset. Anaphylaxis, acute urticaria, dyspnea, and hypotension have occurred in association with infusions of REMICADE®. Medications for the treatment of hypersensitivity reactions should be available.


Serious cerebrovascular accidents, myocardial ischemia/infarction (some fatal), hypotension, hypertension, and arrhythmias have been reported during and within 24 hours of initiation of REMICADE® infusion. Cases of transient visual loss have been reported during or within 2 hours of REMICADE® infusion. Monitor patients during infusion and if a serious reaction occurs, discontinue infusion. Manage reactions according to signs and symptoms.


TNF blockers, including REMICADE®, have been associated with CNS manifestation of systemic vasculitis, seizure, and new onset or exacerbation of CNS demyelinating disorders, including multiple sclerosis and optic neuritis, and peripheral demyelinating disorders, including Guillain-Barré syndrome. Exercise caution when considering REMICADE® in patients with these disorders and consider discontinuation if these disorders develop.


Concurrent use of REMICADE® with anakinra, abatacept, tocilizumab, or other biologics used to treat the same conditions as REMICADE® is not recommended because of the possibility of an increased risk of infection. Care should be taken when switching from one biologic to another, since overlapping biological activity may further increase the risk of infection.


Treatment with REMICADE® may result in the formation of autoantibodies and in the development of a lupus-like syndrome. Discontinue treatment if symptoms of a lupus-like syndrome develop.


Prior to initiating REMICADE®, update vaccinations in accordance with current vaccination guidelines. Live vaccines or therapeutic infectious agents should not be given with REMICADE® due to the possibility of clinical infections, including disseminated infections.

At least a 6-month waiting period following birth is recommended before the administration of any live vaccine to infants exposed in utero to REMICADE®.


In clinical trials, the most common adverse reactions occurring in >10% of REMICADE®-treated patients included infections (eg, upper respiratory, sinusitis, and pharyngitis), infusion-related reactions, headache, and abdominal pain.

For more information, please see the full Prescribing Information and Medication Guide for REMICADE®. Provide the Medication Guide to your patients and encourage discussion. 

References: 1. American Thoracic Society, Centers for Disease Control and Prevention. Targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med. 2000;161:S221-S247. 2. See latest Centers for Disease Control guidelines and recommendations for tuberculosis testing in immunocompromised patients.